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Endocrine Abstracts

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ea0056p142 | Endocrine tumours and neoplasia | ECE2018

Clinical features of ‘dedifferentiation’ in advanced pancreatic neuroendocrine neoplasms: the experience of two centers of excellence

Alexandraki Krystallenia , Grozinsky-Glasberg Simona , Kaltsatou Maria , Kyriakopoulos Georgios , Vergadis Chrysovalantis , Pappas Paris , Mavroeidi Vasiliki , Tsoli Marina , Nikolopoulos Georgios , Angelousi Anna , Kostopoulou Akrivi , Choreftaki Theodosia , Rondogianni Dimitra , Delladetsima Johanna Kassiani , Kaltsas Gregory

Introduction: Neuroendocrine neoplasms (NENs) exhibit significant heterogeneity in growth rates. Clinical and histopathological dedifferentiation has been documented but their clinical characteristics have not been described.Aim of the study: The identification of clinical features of a series of pancreatic NENs (pNENs) that developed dedifferentiation during their course.Methods: Fourteen patients (eight males) with mean age(&#177...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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